Effects of 8-week Sensory Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- Fugl-Meyer Assessment for Upper Extremity
研究概览
简要总结
This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).
详细描述
Subjects were randomly assigned into ES and control groups. Both groups received 20-minute hand function training twice a week, and the ES group received 40-minute ES on the median nerve of the affected side before each training session. The control group received sham ES - electrodes were placed on the same location but no electric current was applied. EEG, EMG and Fugl-Meyer Assessment (FMA) were collected before, at the 4th week, at the end of 8th week, and 4 weeks after the end of intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •first-ever cerebral cortical region involved chronic stroke, onset over a month,
- •able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and
- •at stable medical condition for intervention
排除标准
- •history of other neurological disorders,
- •cognitive impairment (Mini-Mental State Examination score <24, MMSE),26
- •unable to follow orders,
- •contraindications of ES, and
- •under 20 years old
研究组 & 干预措施
Electrical stimulation
干预措施: Electrical stimulation (Other)
Control
干预措施: Sham electrical stimulation (Other)
结局指标
主要结局
Fugl-Meyer Assessment for Upper Extremity
时间窗: before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended
evaluate changes in upper extremity function of the stroke subjects
EEG-EMG coherence
时间窗: before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended
evaluate changes in functional connectivity between motor cortex and active muscles
次要结局
未报告次要终点
研究者
Li-Wei Chou
Associate professor
National Yang Ming Chiao Tung University