Lutein and Oxidative Stress in Alzheimer's Disease - A Pilot Study
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- oxidative damage markers
研究概览
简要总结
Oxidative damage by free radicals may be involved in causing Alzheimer's disease (AD). Free radicals may lead to death of nerve cells and decline in brain function. Certain antioxidants may suppress this free radical damage associated with AD. Carotenoids are a family of naturally occurring antioxidants that have important functions for human health. Carotenoids are known to reduce oxidative damage, but their effects have not been studied in AD patients.
The objective of the study is to examine whether lutein supplementation helps to reduce oxidative damage from free radicals in AD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with moderately severe Alzheimer's disease
排除标准
- 未提供
研究组 & 干预措施
1
Daily Lutein/zeaxanthin supplementation with a meal
干预措施: lutein/zeaxanthin (Dietary Supplement)
2
干预措施: placebo (Dietary Supplement)
结局指标
主要结局
oxidative damage markers
时间窗: 3 months
次要结局
未报告次要终点