Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Blood Pressure
研究概览
简要总结
- Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen.
- Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases.
- Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source.
- The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term.
- In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature.
- For this aim, the investigators will conduct a cross-over trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Reside in Seoul
- •Who provided Informed consent
排除标准
- •Who has cancer
- •Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
- •Who does not provieded informed consent
研究组 & 干预措施
Can 2
Consume two canned beverage first and cross over to other interventions
干预措施: Glass (Other)
Can 2
Consume two canned beverage first and cross over to other interventions
干预措施: Can 2 (Other)
Glass
consume beverage in glass first and cross over to other interventions
干预措施: Can 1 (Other)
Glass
consume beverage in glass first and cross over to other interventions
干预措施: Can 2 (Other)
Glass
consume beverage in glass first and cross over to other interventions
干预措施: Glass (Other)
Can 1
consume one canned beverage and a glass bottled beverage first and cross over to other interventions
干预措施: Can 1 (Other)
Can 1
consume one canned beverage and a glass bottled beverage first and cross over to other interventions
干预措施: Can 2 (Other)
Can 1
consume one canned beverage and a glass bottled beverage first and cross over to other interventions
干预措施: Glass (Other)
Can 2
Consume two canned beverage first and cross over to other interventions
干预措施: Can 1 (Other)
结局指标
主要结局
Blood Pressure
时间窗: 2 hours after consuming beverage
次要结局
- Heart Rate Variablility(2 hours after consuming the beverage)
- Percent DNA methylation(2 hours after consuming the beverage)
研究者
Yun-Chul Hong
Professor
Seoul National University Hospital