Effect of Non-Surgical Periodontal Treatment on Adipokine Levels in Diabetes Mellitus: A Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 4
- 主要终点
- Serum and Salivary Resistin Levels (pg/ml)
研究概览
简要总结
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
详细描述
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diabetes mellitus should be diagnosed for ≥1 year and HbA1c level should be at least %6,5
- •Periodontitis should be diagnosed for at least 4 teeth with probing depth ≥5 mm with bleeding on probing (BOP) and also radiographic alveolar bone loss should be presence
- •Presence of at least 15 teeth
排除标准
- •Received antibiotic treatment in the previous 3 months
- •Pregnancy and lactation
- •Received periodontal treatment in the previous 6 months
- •Presence of less than 15 teeth
- •Having major diabetic complications
结局指标
主要结局
Serum and Salivary Resistin Levels (pg/ml)
时间窗: Change between baseline, 1 and 3 months after non-surgical periodontal treatment
Serum and salivary resistin levels
Serum and Salivary Leptin Levels (pg/ml)
时间窗: Change baseline, 1 and 3 months after non-surgical periodontal treatment
Serum and salivary leptin levels
Serum and Salivary Visfatin Levels (pg/ml)
时间窗: Change baseline, 1 and 3 months after non-surgical periodontal treatment
Serum and salivary visfatin levels
Serum and saliva IL-1β levels (pg/ml)
时间窗: Change baseline, 1 and 3 months after non-surgical periodontal treatment
Serum and salivary IL-1β levels
次要结局
- HbA1c ( %)(Change baseline, 1 and 3 months after non-surgical periodontal treatment)