Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- To collect blood samples
研究概览
简要总结
This is a single-center study at the Cleveland Clinic Main Campus designed to study biomarkers in healthy individuals to identify novel mechanisms of platelet activation and how platelets drive vascular inflammation and thrombosis in diseases.
详细描述
Our past studies have discovered novel platelet activation pathways that may be targets of therapeutic development. We have also defined an important role for a shift in platelet phenotype in vascular disease. Our studies use both in vivo animal models and validation using human platelets from isolated blood. Platelets from healthy individuals may be compared to patients with vascular diseases in the IRB approved protocol "Vascular Lab Resource" (IRB #19-1451) study which is actively recruiting patients at the Cleveland Clinic Main Campus and studies patients with vascular diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 65 years old
- •Healthy Male & Female voluntary participants
排除标准
- •Individuals who have taken anticoagulant or antiplatelet medications in past 10 days
- •Individuals with hematopoetic diseases
结局指标
主要结局
To collect blood samples
时间窗: 10 years
To establish a biorepository for normal healthy cohort of subjects
次要结局
未报告次要终点
研究者
Scott Cameron, MD, PhD
Principal Investigator
The Cleveland Clinic