NCT01878721已完成不适用
Positron Emission Tomography of Infection and Vasculitis (PETU)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 117
- 试验地点
- 1
- 主要终点
- Detection of infection or vasculitis in PET images
研究概览
简要总结
The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.
详细描述
The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:
- investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.
- study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.
- find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.
- study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.
- investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with
- •Staphylococcus aureus bacteremia or
- •Salmonella spp. bacteremia or
- •infective endocarditis or
- •infection of pacemaker or implantable cardioverter defibrillator or
- •vasculitis
排除标准
- •underage, pregnant, breastfeeding, handicapped or prisoner
结局指标
主要结局
Detection of infection or vasculitis in PET images
时间窗: within 1 week after starting the treatment
次要结局
- Standardized uptake value of PET imaging agent at the site of infection or vasculitis(within 1 week after starting the treatment)
研究者
Anne Roivainen
professor
Turku University Hospital
研究点 (1)
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