Predictive Value of Epicardial Fat Thickness for Disease Severity in Coronary Artery Disease Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients.
研究概览
简要总结
is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients
详细描述
epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries.
epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •contraindication for cardiac magnetic resonance.
- •Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission
- •history of chronic kidney disease with glomerular filtration rate <30 mL/min
- •pericardial and/or pleural effusion.
结局指标
主要结局
measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients.
时间窗: one year
epicardial adipose tissue measurement using transthoracic echocardiography and cardiac magnetic resonance
次要结局
未报告次要终点
研究者
Osama Fekry
principal investigator
Assiut University