ACTRN12618000051246已完成1 期
The effect of sublingual atropine sulfate on the rate of saliva secretion in patients with schizophrenia who are found to have Clozapine-Induced Hypersalivation and/or Drooling
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 21
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Non pregnant and non-breast feeding adults 18 or more year old,
- •2. Treated with clozapine.
- •3. Hypersalivation or drooling started after starting clozapine, and the treating psychiatry physician believes it is most likely due to clozapine therapy.
- •Hypersalivation or drooling is identified through either: Screening patients treated with clozapine for clozapine-induced hypersalivation or drooling as per the screening protocol. Or Examining patient for clozapine-induced hypersalivation or drooling after it is reported by the patient, healthcare team, or carers
- •4. Consents ,willingly, to participate in the study
- •5. The treating psychiatry physician chooses to enrol the patient in the study
- •Note: all patients treated with clozapine must have schizophrenia
排除标准
- •1.Pregnant, breast feeding, or < 18 year old
- •2.Allergy to atropine or chloramphenicol.
- •3.Has any of the following disease:
- •Anaemia, diarrhoea (suggestive of pseudomembranous colitis), neutropaenia (suggestive of bone marrow suppression), Narrow-Angle Glaucoma, Myasthenia Gravis, Prostatic Hypertrophy, bladder obstruction, Glucose-6-Phosphate Dehydrogenase (G-6-PD) Deficiency, GI obstructive disease such as ileus, or other medical illness that may be seriously adversely affected by atropine or quinine.
- •4.Treated with an anticoagulants or antiarrhythmics.
- •5.Have been given or started on any medication known to have an anticholinergic effect after the detection of hypersalivation or drooling
研究者
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