Assessment of the effect of sublingual isosorbide dinitrate with indomethacin suppository on post Endoscopic retrograde colangiopancreatography pancreatitis
Phase 3
- Conditions
- pancreatitis.Idiopathic acute pancreatitis
- Registration Number
- IRCT138810082931N1
- Lead Sponsor
- Digestive disease research center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Study populations are all patients referred to Shariati hospital who undergo therapeutic or diagnostic ERCP in endoscopy ward.
Exclusion criteria: age<18; HX of nitrate use; HX of recent acute pancreatitis (less than one month); HX of chronic pancreatitis; recent (2weeks) peptic ulcer bleeding; HX of glaucoma; ampullary tumor; use of sildenafil; unwilling for consent; allergy to drugs; previous sphincterotomy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post ercp pancratitis. Timepoint: 24 hours after ercp. Method of measurement: pain observative scale, serum amylase measurement, hospitalation period.
- Secondary Outcome Measures
Name Time Method ausea and vomiting. Timepoint: 24 hours after procedure. Method of measurement: asking from patient.;Fever/chills. Timepoint: 2 and 24 hours after procedure. Method of measurement: check of fever grade with termometer.;Upper GI bleeding. Timepoint: 2 and 24 hours after procedure. Method of measurement: check of vital sighns, hematemesis and melena.