Neutrophil-lymphocyte Ratio Versus Lactate-albumin Ratio as a Predictor of Morbidity and Mortality in Patients With Sepsis and Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Prediction of 28 day mortality.
研究概览
简要总结
The aim of the study is to compare between neutrophil lymphocyte ratio and lactate albumin ratio as a predictor of morbidity and mortality in sepsis and septic shock patients.
详细描述
Sepsis is a systemic inflammatory response syndrome caused by infection can lead to life threatening multi-organ dysfunction.
Septic shock causes circulatory and metabolic abnormalities, leading to increased mortality in hospitalized patients, especially in intensive care unit (ICU) patients.
Sepsis can affect the function and number of immune cells, including neutrophils, lymphocytes and monocytes.
Neutrophils play crucial roles in the innate cellular immune system. Early higher neutrophil counts correlated with increased sepsis severity.
In sepsis, lymphocytes decrease owing to the apoptosis mediated by innate response.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Prediction of 28 day mortality.
时间窗: 28 days
Prediction of 28 day mortality (patients will be followed by telephone for 28 day after discharge).
次要结局
- Extent of organ dysfunction in patients with sepsis and septic shock assessed by SOFA score(0 hours, 6 hours, 24 hours of admission to icu)
研究者
Walaa Adel Abdelghafar Elbialy
Principal Investigator
Tanta University