NCT02752477Unknown3 期
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Pain in Chronic Pain Patients Undergoing Spinal Surgery: A Pilot Study
Ben Lim1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2016年8月2日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Quantified opioid-consumption
研究概览
简要总结
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic pain patients (CPPs) undergoing spine surgery when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative opioid consumption and pain scores in CPPs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic pain > 6 months, opiate-using patients scheduled for thoracic or lumbar spinal surgery
排除标准
- •Pregnant or breastfeeding women, significant hepatic, renal or cardiac disease, allergy to any of the study drugs, inability to consent, respond to pain assessments or use the patient controlled analgesia device
研究组 & 干预措施
Opioid-free anesthetic (OFA) group
Experimental
干预措施: Opioid-free general anesthetic (Drug)
Traditional Anesthesia (TA) group
Active Comparator
干预措施: Traditional general anesthetic (Drug)
结局指标
主要结局
Quantified opioid-consumption
时间窗: 48 hours following surgery
次要结局
- Time of stay in post-anesthetic care unit (PACU)(up to 5 hours following surgery)
- Visual analogue scale (VAS) pain scores(48 hours following surgery)
- Incidence of adverse events(48 hours following surgery)
研究者
Ben Lim
Anesthesiologist
University of Saskatchewan
研究点 (1)
Loading locations...
相似试验
已完成
3 期
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing TonsillectomyPathologic ProcessesAnesthesiaGeneral AnesthesiaAnalgesics, OpioidPostoperative ComplicationsPhysiologic Effects of DrugsNarcoticsAnalgesicsSleep Disordered BreathingObstructive Sleep Apnea of ChildTonsillectomyRespiratory DepressionDexmedetomidineKetamineLidocaineGabapentinPulse OximetryNCT02987985University of Saskatchewan50
已完成
不适用
Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic SurgeryPostoperative Nausea and VomitingOpioid UseThoracic DiseasesNCT05411159Beijing Chao Yang Hospital168
招募中
3 期
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal SurgeryAnesthesiaGeneral AnesthesiaAnalgesics, OpioidOpioid Free AnesthesiaPostoperative IleusColorectal SurgeryLaparoscopic SurgeryAnalgesiaDexmedetomidineLidocaineKetamineNCT04144933University of Saskatchewan60
尚未招募
Unknown
Post operative pain relief using Diclofenac, Lignocaine and Dexmedetomidine and Fentanyl.CTRI/2023/10/058649Dr Deepak
已完成
不适用
Opioid Free Anesthesia in Maxillofacial SurgeryMaxillofacial SurgeryNCT05031676Université NAZI BONI66