Physiological Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Relapse Severity
研究概览
简要总结
Alcohol dependence is among the most common and costly public health problems affecting the nation. Among individuals with alcohol use disorder (AUD), those with (vs. without) a co-occurring anxiety disorder (AnxD) are as much as twice as likely to relapse in the months following AUD treatment. Dysregulation of biological stress-mood systems predict and correlate with AUD relapse and AnxD symptomatology. In contrast, stress system re-regulation correlates with improved AUD treatment outcomes but has not been examined with respect to AUD recovery and relapse in co-occurring AUD+AnxD.
详细描述
The objectives of the proposed research are to 1) evaluate the effect of co-occurring AnxD on the severity of biological stress-mood system dysregulations in AUD inpatients at pre-treatment, 2) evaluate the effect of co-occurring AnxD on the persistence of stress-mood system dysregulations in AUD inpatients in the months following treatment, 3) evaluate the effects of treatment on biological stress-mood system re-regulation among AUD patients with co-occurring AnxD, and 4) evaluate the effect of re-regulation change in biological stress-mood system function on AUD clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ability to provide informed consent
- •Between the ages of 18 and 65
- •Diagnostic and Statistical Manual diagnosis of a Panic Disorder, Generalized Anxiety Disorder, or Social Anxiety Disorder within the past 30 days (AUD+AnxD group only).
- •Primary alcohol use disorder diagnosis and alcohol use in the 30 days preceding the study (AUD alone and AUD+AnxD groups only).
- •Inpatient treatment at Lodging Plus primarily for alcohol (vs. other drug with nicotine accepted) dependence (AUD alone and AUD+AnxD groups only).
- •A minimum of a sixth-grade reading level.
- •Healthy controls, same criteria absent AUD and AnxD diagnosis of an alcohol and/or anxiety disorder
- •Lives within proximity to the Twin Cities (e.g., within about an hour's drive) or willing to drive to Fairview for the purpose of attending follow-up visits
- •Willingness to provide contact information to confirm follow-up appointments
排除标准
- •Lifetime history of psychosis or mania
- •Cognitive impairment, physical impairment, or chronic medical illness that precludes study participation
- •Primary PTSD as determined by qualifying assessment
- •Females currently pregnant
- •Exposure to antipsychotic medication for a total duration >16 weeks.
- •Prior head injury leading to >30 minutes of unconsciousness.
- •Cognitive impairment that impedes study participation.
- •Healthy controls with a history of any major medical or psychiatric disorders (e.g., schizophrenia, depression, heart disease, or stroke).
- •Suicide intent or attempt in the past 30 days
- •Cardiovascular health issues
- •Thyroid Disease
- •History of severe neurological illness such as chronic seizure disorder (e.g, epilepsy) or stroke
- •Brain tumor and/or implants in the skull cavity (e.g., plate in the skull)
- •Pacemaker
结局指标
主要结局
Relapse Severity
时间窗: 4-month follow-up
Relapse severity will consist of the number days drinking during the 4 months following treatment discharge.
Relapse Status
时间窗: 4-month follow-up
Relapse status will be assessed using a categorical measure of whether someone did vs did not drink (yes vs. no) during the 4 months following treatment discharge.
次要结局
未报告次要终点