Renal Considerations in the Heat Stress Recommendations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Peak urinary [IGFBP7•TIMP-2]
研究概览
简要总结
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration. The current heat stress recommendations for workers were not developed with regards for kidney health. The purpose of this study is to determine if the current recommendations protect against kidney dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
The participant will not be directly informed of the experimental conditions and will be blinded to the hypotheses.
The outcomes assessor will be blinded to the experimental conditions when analyzing the data.
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women
- •18-44 y old
- •Body mass index ≤35.0 kg/m2
- •Self-reported to be healthy.
排除标准
- •Not within defined age range
- •Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
- •Deemed highly active according to the physical activity questionnaire (i.e., >3500 MET*min/wk)
- •Body mass index >35.0 kg/m2
- •Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
- •Hypertension during screening (systolic blood pressure >139 or diastolic blood pressure >89)
- •Using medications that blunt the physiological response to exercise (e.g., beta blockers)
- •Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
- •Positive pregnancy test at any time during the study or breast feeding
- •Current tobacco or electronic cigarette use or consistent use within the last 2 years
- •Inability to safely complete the peak oxygen uptake test
结局指标
主要结局
Peak urinary [IGFBP7•TIMP-2]
时间窗: through study completion, up to 20 weeks
Kidney injury marker
次要结局
- Urinary IL-18(through study completion, up to 20 weeks)
- Urinary NGAL(through study completion, up to 20 weeks)
- Urinary TIMP-2(through study completion, up to 20 weeks)
- Renal artery blood velocity(through study completion, up to 20 weeks)
- Urinary L-FABP(through study completion, up to 20 weeks)
- Urinary IGFBP7(through study completion, up to 20 weeks)
- Segmental artery blood velocity(through study completion, up to 20 weeks)
研究者
Zachary J. Schlader
Associate Professor of Kinesiology
Indiana University