Probiotic Intervention for Children With Birch Pollen Allergy
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 47
- 试验地点
- 2
- 主要终点
- Birch pollen allergy symptoms
研究概览
简要总结
Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy.
Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 2 Years 至 10 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physician verified birch pollen allergy
排除标准
- •Diagnosed asthma Habitual use of probiotics and/or prebiotics
结局指标
主要结局
Birch pollen allergy symptoms
时间窗: March/April and June
Nasal Eosinophilia
时间窗: April/May and June
次要结局
- Change in microbiota composition(April/May and June)
- Cytokine profile from serum(April/May and June)
- Faecal recovery of administered probiotics(April/May and June)
