跳至主要内容
临床试验/NCT00746226
NCT00746226已完成1 期

Probiotic Intervention for Children With Birch Pollen Allergy

Danisco2 个研究点 分布在 1 个国家目标入组 47 人开始时间: 2006年3月1日最近更新:
适应症

试验速览

阶段
1 期
状态
已完成
发起方
入组人数
47
试验地点
2
主要终点
Birch pollen allergy symptoms

研究概览

简要总结

Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy.

Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
2 Years 至 10 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Physician verified birch pollen allergy

排除标准

  • Diagnosed asthma Habitual use of probiotics and/or prebiotics

结局指标

主要结局

Birch pollen allergy symptoms

时间窗: March/April and June

Nasal Eosinophilia

时间窗: April/May and June

次要结局

  • Change in microbiota composition(April/May and June)
  • Cytokine profile from serum(April/May and June)
  • Faecal recovery of administered probiotics(April/May and June)

研究者

发起方
Danisco
申办方类型
Industry

研究点 (2)

Loading locations...

相似试验