Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 主要终点
- Cerebral blood flow
研究概览
简要总结
This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine (used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive testing will also be obtained, and correlated with the blood flow patterns in the brain.
详细描述
Project Summary: This research project will investigate the value of combined pharmacologic manipulation and arterial spin-labeled perfusion MRI (pharmacologic ASL-pMRI) as an in vivo probe of cholinergic function. Methods to investigate cholinergic function in vivo are needed to better understand the role of acetylcholine in the physiology of the cerebral cortex, and in cognitive processes in health and in disease states. In this study, pharmacologic ASL-pMRI will be used to characterize the normal cerebral perfusion response to cholinergic manipulation in young healthy subjects. Cognitive measures will also be obtained and correlated with cerebral perfusion changes. Pharmacologic ASL-pMRI and cognitive testing will then be used to study how the cholinergic response is altered with normal aging and in delirium
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
排除标准
- •Any neurological condition, such as brain tumor, history of stroke, seizure disorder, attention deficit disorder, normal pressure hydrocephalus, dementia, traumatic brain injury
- •Any major medical conditions, such a cancer, diabetes, glaucoma, prostate disease, uncontrolled hypertension
- •antihistamine use
- •tricyclic antidepressant use
- •presence of metal in body, including pacemaker, defibrillator, neurostimulator, metal implants, or foreign metal objects such as bullets or shrapnel.
- •anxiety or panic disorder
- •history of claustrophobia
- •pregnancy
研究组 & 干预措施
Older
Older healthy controls, aged 65-80
干预措施: Donepezil (Drug)
Young
Young healthy controls, aged 21-35
干预措施: Scopolamine (Drug)
Young
Young healthy controls, aged 21-35
干预措施: Placebo (Drug)
Older
Older healthy controls, aged 65-80
干预措施: Scopolamine (Drug)
Older
Older healthy controls, aged 65-80
干预措施: Placebo (Drug)
结局指标
主要结局
Cerebral blood flow
时间窗: 3 hours
cerebral blood flow will be measured 3 hours after drug administration using Arterial spin-labeled perfusion MRI
次要结局
- cognitive performance(4 hours)
研究者
Tamara Fong
Assistant Scientist/Assistant Professor of Neurology
Hebrew SeniorLife