Decreased Tongue Strength is Related to Skeletal Muscle Mass in COPD Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- maximum tongue pressure
研究概览
简要总结
Background:
Dysphagia is frequently observed in subjects with chronic obstructive pulmonary disease (COPD). But tongue strength has not been investigated yet in COPD subjects. The investigators hypothesized that tongue strength is weaker in COPD subjects compared to normal subjects.
Methods:
This was a single-centre, observational, and cross-sectional study. Twenty-seven subjects with COPD and twenty-four age-matched control subjects were enrolled in this study. Isometric tongue strength was measured using a device fitted with a disposable oral balloon probe. The investigators also evaluated handgrip strength, gait speed, and appendicular skeletal muscle mass (ASM) to define participants as having sarcopenia. ASM, fat free mass index (FFMI), and skeletal muscle mass index (SMI) were measured by bioelectrical impedance analysis. Gait speed was measured using the 6-meter walking test. The eating assessment test-10 (EAT-10) was used to diagnose dysphagia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of stable COPD.
- •Age-matched control subjects who did not have any pulmonary disease.
排除标准
- •Participants with metallic implants.
- •History of stroke disease.
- •History of neuromuscular disease.
- •Participants who did not have their front teeth.
结局指标
主要结局
maximum tongue pressure
时间窗: 1 day
To measure maximum tongue pressure (MTP), the balloon was positioned on the anterior palate with the lips closed. Subjects raised their tongue and compressed the balloon onto the palate with maximal voluntary muscular effort for approximately 7s. The measurement was taken three times with a 1-min interval. The maximum value was recorded as the MTP.
次要结局
- fat free mass index (FFMI)(1 day)
- skeletal muscle mass(1 day)
- height(1 day)
- handgrip strength(1 day)
- skeletal muscle mass (SMI)(1 day)
- fat free mass(1 day)