Renal Doppler in Detection of Steroid Resistance in Pediatric Patients With Idiopathic Nephrotic Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- detection of steroid resistance in pediatric patients with idiopathic nephrotic syndrome
研究概览
简要总结
The use of the renal resistive index in pediatric patient with idiopathic nephrotic syndrome to detect steroid resistance and to use it as a prognostic instrument of the progression of the disease.
详细描述
Renal Doppler will be done for all children in supine and lateral positions using Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity) at diagnosis, after one month, 3 months and 6months, in which these values will be obtained by the ultrasound machine based on the computer algorithm. Also the kidneys will be scanned firstly for length, width, cortical thickness and echogenicity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pediatric patients with primary nephrotic syndrome aged from 1 to 18 years
排除标准
- •- Patients with congenital nephrotic syndrome.
- •Patients with secondary causes of nephrotic syndrome.
结局指标
主要结局
detection of steroid resistance in pediatric patients with idiopathic nephrotic syndrome
时间窗: 6 weeks
measurement of renal resistive index and detection of steroid sensitivity
次要结局
- progression of nephrotic syndrome(six months)
研究者
Sara Mabrouk Elghoul
Tanta, Stadium Street
Tanta University