Development and Evaluation of Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit (Salacca Edulis Reinw.)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 178
- 试验地点
- 2
- 主要终点
- Level of skin elasticity
研究概览
简要总结
This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.
详细描述
Study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks.
Study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.
Study 3: this study was divided into 2 sub-stidies. Study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. All participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. After each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Man or woman
- •Aged between 18 to 35 years
- •Interested in body massage with oil or facial mask or jelly from Snake fruit
排除标准
- •History of adverse effects from body massage
- •Skin allergy
- •Skin disorders
- •Skin wounds
- •History of allergy to coconut or plant oil
- •History of allergy to facial mask, i.e., mask from fruit
- •History of allergy to Snake fruit or gelatin
- •Signs or symptoms of fever or infection
- •Abnormal body mass index
- •Regular smokers or alcohol drinkers (>2 times per week)
- •Regular exerciser (>2 times per week or >150 min per week)
- •Regular intake of dietary supplements, i.e., vitamins, antioxidants
- •Hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer
结局指标
主要结局
Level of skin elasticity
时间窗: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe
Level of skin moisture
时间窗: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe
Level of skin melanin
时间窗: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe
Endurance time
时间窗: After jelly consumption for 30 minutes
Study 3.2 determined endurance time by cycling at 60% of maximum oxygen consumption as long as possible (time to exhaustion test)
Concentration of tumor necrosis factor-alpha
时间窗: Before and immediately after endurance time test
Study 3.2 determined concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit
Level of skin oiliness
时间窗: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe
Concentration of interferon-gamma
时间窗: Before and immediately after endurance time test
Study 3.2 determined concentration of interferon-gamma in serum in pg (picogram)/mL unit
Level of blood glucose
时间窗: Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes
Study 3.1 determined level of blood glucose in mg/dL unit
次要结局
未报告次要终点
研究者
Piyapong Prasertsri
Associate Professor Dr.
Burapha University