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临床试验/NCT04354623
NCT04354623已完成不适用

Developing a Falls Prediction Tool Using Both Accelerometer and Video Gait Analysis Data in Older Adults

University of British Columbia2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年4月15日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
2
主要终点
Classification of accuracy of the algorithm on the validation dataset

研究概览

简要总结

Our group, consisting of academic clinicians and research engineers, seeks to create a database of stability measures (accelerometers, gyroscopes and altitude sensor data) in older adults monitored longitudinally. This Stability Measures (SM) database will allow us to use new machine learning methods to develop and then validate algorithms that predict future falls, allowing for better targeting of vulnerable patients.

详细描述

Recent advances in machine learning have disrupted the standard approach to assessing medical prognosis. Our group, consisting of academic clinicians and research engineers, seeks to create a database of stability measures ( accelerometers, gyroscopes and altitude sensors data) in older adults monitores longitudinally. This Stability Measures (SM) database will allow us to use new machine learning methods to develop and validate algorithms that predict future falls, allowing to better targetting of vulnerable individuals.

Although there have been numerous attempts to quantify fall risk in older adults using bedside scales 7-12, no previous group has attempted to use a combination of both accelerometer and video measures to assess gait stability. Since these measures will be captured in both frequently falling and infrequently falling patients, we will have SM data for various windows of time (1, 2, 3 and 4-weeks) prior to at least 100 fall events, a dataset that has never been captured before.

HYPOTHESES:

  1. A combination of accelerometer, gyroscope, and video data can be used to predict falls longitudinally, first by the use of a training dataset followed by verification on a validation data set.
  2. All the above sensor-based inputs can be combined as a simple, automated predcition tool to predict fall risk in older adults Current Methods of Falls Risk Assessment: Current methods of predicting falls in physician offices rely heavily on simple bedside tests12-14. Although useful, all of these measures have quite low sensitivity and specificity, with an Area Under the Curve (AUC) of approximately 0.707-12.

In fact, a recent meta-analysis "could not identify any tool which had an optimal balance between sensitivity and specificity, or which was clearly better than a simple clinical judgment of risk of falling"

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • All subjects must be aged 65 years and older • All subjects must have had at least one fall in the last year and have been referred to the falls clinic (High Risk Subjects) OR have had no falls on the last year and have responded to our newspaper advertisement (Low Risk Subjects)

排除标准

  • Subjects age less than 65 years old

研究组 & 干预措施

High Risk Subjects (n=50)

All subjects will be recruited from falls and geriatrics clinics at Vancouver General Hospital. These clinics see about 2500 patients per year and are currently used for research recruitment. Each clinic patient has gait speed measured, which will allow to recruit both high and low risk fallers. This test will allow us to recruit 50 subjects at marked risk for falls, providing us with prospectively gathered dataset of greater than 100 events, five times higher than any other sensor study.

干预措施: A 6-minute walk test (Other)

Low Risk Subjects (n=50)

We will use newspaper advertisements to recruit and then screen low risk subjects. All subjects will have a gait speed > 0.8 m/s and have had no falls in the last year.

干预措施: A 6-minute walk test (Other)

结局指标

主要结局

Classification of accuracy of the algorithm on the validation dataset

时间窗: 60 min

Consisting of True positive (TP), False positive (FP) rate, Precision, Recall (similar to sensitivity), F-measure (conveys the balance between precision and recall) and the Receiver Operation Curve area

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Kenneth Madden

Division Head, Vancouver General Hospital Division of Geriatric Medicine Department of Medicine University of British Columbia

University of British Columbia

研究点 (2)

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