Comparison to Short and Medium-term Effects of Continuous and Interval Aerobic Exercise Training in Improving Aerobic Capacity, Psychosocial Factors and Impact on the Level of Physical Activity in Patients With Asthma Moderate and Severe
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- Endurance test
研究概览
简要总结
The treatment of asthma is based in clinical control. However, previous studies have been shown that patients that participate of the programs of regular or aerobic continuous exercise training (CT) presented improvements in the physical conditioning, and quality life, as well as decreased the levels of anxiety and depression, reduced the oxide nitric exhaled and leukocyte migration at the airways and reduced the airway hyperresponsiveness. The regular exercise also is important part in the rehabilitation of other lung disease as well as chronic obstructive pulmonary disease (COPD). Additionally, others studies have been shown the effects of high intensity interval training (IT) in the pulmonary rehabilitation of COPD patients, that after performed IT presented reduction of dyspnea, and increase the physical capacity. In this sense, the impact of IT in the asthmatic patients at the present moment is poorly studied, and necessity of the more investigation to prove the efficiency of this training model for asthma patients.
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详细描述
The present study will compare the impact of IT and CT in patients with moderate or severe asthma, and investigate what is the most efficient and increases the physical capacity, and quality of life and reduces the inflammatory mediators.
Sixty asthmatic adults will be randomly assigned into two groups: CT (Continuous training) or IT (Interval training). CT will have treatment 2x week, 40 min./session, 60-75% of maximum heart rate intensity and IT also 2x week, 40 min./session, 80-140% of the maximum load intensity, both performed in ergometer cycle by 24 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Asthma moderate and severe
- •Asthma will diagnosed (Global Initiative for Asthma - GINA)
- •Body Mass Index (BMI) < 35kg/m2
- •Medical Treatment for at least 6 months
- •Clinically stable (i.e., no exacerbation or medication changes for at least 30 days)
排除标准
- •Cardiovascular, musculoskeletal or other different chronic lung diseases
- •Active cancer
研究组 & 干预措施
Continuous Exercise Training
The interventions of active comparator will be education program and exercise training.
干预措施: Continuous Exercise Training (Other)
Continuous Exercise Training
The interventions of active comparator will be education program and exercise training.
干预措施: Education Program (Behavioral)
Interval Exercise Training
The interventions of active comparator will be education program and exercise training.
干预措施: Interval Exercise Training (Other)
Interval Exercise Training
The interventions of active comparator will be education program and exercise training.
干预措施: Education Program (Behavioral)
结局指标
主要结局
Endurance test
时间窗: After 3 months of intervention
Measurements at isotime: at identical work rates before and after training, heart rate, perception exertion and dyspnea.
次要结局
- Health related quality of life(Before and after 3 months os intervention, and after 3 months of follow up)
- Nitric oxide exhaled measurement(Before and after 3 months of intervention)
- Analysis of cortisol in the serum(Before and after 3 months of intervention)
- Level of physical activity(Before and after 3 months of intervention, and after 3 months of follow up)
- Lung function(Before and after 3 months os intervention, and after 3 months of follow up)
- Quantification of Inflammatory mediators(Before and after 3 months of intervention)
- Clinical Control(Before and after 3 months os intervention, ans after 3 months of follow up)
- Level of depression and anxiety(Before and after 3 months os intervention, and after 3 months of follow up)
- Physical capacity(Before and after 3 months os intervention)