Shifting pain modulation towards anti-nociceptivity: Mechanism-specific pharmacological prevention of post sternotomy pain: the MASTER study - MASTER

eiden University Medical Center0 个研究点开始时间: 2015年2月2日最近更新: 2015年7月10日

适应症

试验速览

暂无简介。

•Patients of either sex with American Society of Anesthesiologists score 1, 2 or 3, aged 18 to 70 years planned to undergo elective surgery involving a sternotomy may be enrolled in the study.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 290
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•1. Pain scores > 3 (on a 11-point numerical rating scale, NRS) reported for most of the day during the past month (including angina);
•2. The presence of any chronic pain disorder;
•3. Regular use of analgesics for any purpose, including SNRIs, gabapentinoids, COX inhibitors or NSAIDs during the previous month;
•4. Use of MAO-inhibitors within the last 14 days;
•5. The presence of narrow-angle glaucoma;
•6. Inability to perform psychophysical testing (eg. in case of cognitive or psychiatric disorders);
•7. Patients suffering from cognitive dysfunction;
•8. Patients being treated for depression, or any other mood disorder;
•9. Inability to give informed consent;
•10. Inability to communicate with the investigators;
•11. Known allergies to the study medication:
•12. Uncontrolled hypertension (diastolic blood pressure > 100 mmHg).

发起方

eiden University Medical Center