Efficacy of Dexmedetomidine for the Therapy of Catheter-related Bladder Discomfort
试验速览
- 阶段
- 4 期
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- The number of patients with catheter-related bladder discomfort
研究概览
简要总结
To evaluate the efficacy of dexmedetomidine for the prevention of catheter-related bladder discomfort
详细描述
After transurethral bladder resection, large-sized foley catheter have been used for drainage of urine and residual blood. Because of urinary catheterization, patients usually experiences catheter-related bladder discomfort defined as a burning sensation with an urge to void or discomfort in the supra-pubic region caused by catheter- related bladder irritation.
Dexmedetomidine is an alpha-2 antagonist and used as an analgesic agent. The investigators try to evaluate The efficacy of dexmedetomidine for the treatment of catheter-related bladder discomfort
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for transurethral bladder resection
- •ASA I-III
排除标准
- •Patient who disagrees to participate this investigation
- •Patient with severe cardiovascular disease
- •Patient with small-sized foley catheter (less than 18 Fr.)
- •Patinets with any urinary tract obstructions
- •Patient with hyperactive or neurogenic bladder
- •Patients with chronic renal failure
- •Patient with morbidly obese
- •Patients with neurogenic disorder
- •Patient with medications for chronic pain
研究组 & 干预措施
Placebo group
NS infusion will be done during surgery.
干预措施: NS infusion (Drug)
Dex group
DEX infusion will be done during surgery.
干预措施: Dex infusion (Drug)
结局指标
主要结局
The number of patients with catheter-related bladder discomfort
时间窗: at postoperative 1 hour
catheter-related bladder discomfort at postoperative 1 hour was evaluated as none, mild, moderate, severe. The number of patients with mild, moderate, severe discomfort will be calculated and compared between groups.
次要结局
- Catheter-related bladder discomfort(at postoperative 0, 1, 6, 24 hours)
- Pain at suprapubic area(at postoperative 0, 1, 6, 24 hours)
研究者
Hee-Pyoung Park
Professor
Seoul National University Hospital