Healing Response of Recipient and Donor Sites in Smokers and Non-Smokers Following Free Gingival Grafting: Adjunctive Effects of Topical Hyaluronic Acid on Palatal Healing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Healing outcome of the palatal donor site
研究概览
简要总结
Comparison of the healing of free gingival grafts applied to smokers and non-smokers and evaluation of the effect of hyaluronic acid gel on healing of the donor site.
详细描述
The oral mucosa consists of three main components: (1) masticatory mucosa, (2) specialized mucosa, and (3) lining mucosa. The masticatory mucosa is a keratinized tissue covering the gingiva and the hard palate. The gingiva itself can be classified into three distinct regions: (1) free gingiva, (2) interdental gingiva, and (3) attached gingiva. The free gingiva is composed of oral epithelium, oral sulcular epithelium, and junctional epithelium. Both the oral epithelium, interdental gingiva, and attached gingiva are keratinized tissues.
Keratinized gingiva can be histologically divided into the following cell layers based on the degree of keratin-producing cell differentiation:
Stratum basale (or stratum germinativum)
Stratum spinosum
Stratum granulosum
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were eligible for inclusion if they were between 18 and 65 years of age, systemically healthy, and not taking regular medication. Additional criteria included the absence of antibiotic use within the last three months, no pregnancy or lactation, a periodontally healthy status or completion of periodontal therapy, and the presence of insufficient keratinised gingiva in the mandibular anterior region (canine-to-canine) with a clinical indication for FGG in the same area. Smoking and non-smoking status were determined from clinical records and patient self-reports. All smokers included in the study continued smoking throughout the documented postoperative period, and none of the non-smokers had a history of smoking or initiated smoking during the study period.
排除标准
- •Subjects who do not meet these conditions will not be included in the study.
结局指标
主要结局
Healing outcome of the palatal donor site
时间窗: Baseline, Day 7 , Day 14, 1. Month, 3. Months
Clinical assessment of epithelialisation using standardised scoring. Assessment of the palatal donor site was undertaken through standardised measurements of graft epithelialisation at predefined intervals using a Williams periodontal probe.
次要结局
- Visual Analogue Scale pain scores(Days 3, 7, 10, and 14 postoperatively)
研究者
Emine Çifcibaşı
Associate Professor
Istanbul University