Expression of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in breast cancer: A case control study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Prevalence of expression of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in case and control population
研究概览
简要总结
Primary purpose: To study expression of Methylenetetrahydrofolate Reductase (MTHFR) C677T gene polymorphism in breast cancer and study its association with histological grade and proliferation index of breast cancer.
Breast cancer, the most common malignancy affecting women worldwide, remains a significant cause of cancer-related deaths. While the precise mechanisms of breast carcinogenesis are not fully understood, it is established that genetic factors interact with environmental influences, determining individual susceptibility. This study focuses on the Methylenetetrahydrofolate reductase gene (MTHFR) and its association with breast cancer. Specifically, the functional single-nucleotide polymorphism (SNP) C677T in the MTHFR gene may impact tumor cell chemosensitivity. The MTHFR enzyme, crucial for intracellular folate homeostasis, catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which serves as a carbon donor for homocysteine methylation to methionine. Additionally, MTHFR plays a vital role in DNA biosynthesis, repair, and maintenance of DNA stability
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- Female
入选标准
- •For cases: Newly diagnosed and histopathologically confirmed cases of invasive ductal carcinoma of breast (IDC); no special type (NST) in female patients presenting with palpable breast lump.
- •For controls: Diseased women brought in for postmortem examination with no past history of breast cancer.
排除标准
- •For cases:
- •Patients who have received radiotherapy, chemotherapy and/or immunotherapy
- •Former history of breast cancer or any other types of cancer For controls:
- •Decomposed/ decayed body
- •Former history of breast cancer or any other types of cancer.
结局指标
主要结局
Prevalence of expression of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in case and control population
时间窗: Baseline
次要结局
- Proportion of expression of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in breast cancer patients and their association with histological grade and proliferation index(Baseline)
研究者
Dr Shaad Vali
Maulana Azad Medical College