Skeletal muscle characterization in frail elderly - Skeletal muscle in frailty

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年5月6日

试验速览

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•frail male, non-obese (BMI <27 kg*m-2) subjects aged 70-90 years, with no history of participating in any regular exercise training program in the past 5 years, meeting 3 or more of these criteria: 1) unintentional weight loss of 10% or more since age of 60 2) self-reported low usual energy level (3 on a 0-10 scale), feeling unusually tired in the last month, or unusually weak in the last month; 3) low energy expenditure, defined as being in the lowest quintile of energy expenditure measured using a six-item version of the Minnesota Leisure Time Activity Questionnaire; 4) slowness, defined as being in the lowest quintile of walking speed over a 4,57-m distance; 5) weakness, defined as being in the lowest quintile of hand grip strength measured using a handheld dynamometer.
•Subjects will be considered non-frail and, as such, eligible for inclusion in the study if 1 or less of the criteria is met (i.e. only non-frail individuals in healthy elderly control group).

•Exclusion criteria are: type I and type II diabetes, the use of anticoagulation, female sex, senile dementia, participation in any regular exercise program.

发起方

Medisch Universitair Ziekenhuis Maastricht