NCT04506892已完成不适用
Quantitation of Glymphatic Functioning in Sleep and Meditative States
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- CSF flow change
研究概览
简要总结
This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.
详细描述
This study is evaluating the glymphatic system during awake, sleep, and meditative states.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
no masking is used in this protocol
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 14-45
- •"Adept meditator status"
排除标准
- •Any non-MR compatible material implant, or contraindication to MR scanning
- •Claustrophobia or inability to lie still for prolonged periods of time
- •Participants with a recent (less than 2 months) infection, tattoo, or wound
- •No consumption of stimulants or alcohol within 12 hours of the study visit
- •clinical diagnosis of any major neurological or psychological condition
- •Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors
结局指标
主要结局
CSF flow change
时间窗: baseline to 24 hours
Using MRI to assess the change in CSF flow in awake, sleep deprived, and meditative states
次要结局
- EEG changes(baseline to 24 hours)
研究者
Daniel Claassen
Associate Professor
Vanderbilt University Medical Center
研究点 (2)
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