跳至主要内容
临床试验/NCT07078578
NCT07078578已完成不适用

Construction of a Machine Learning Prediction Model for Postoperative Delirium in Kidney Transplant Patients Based on Clinical Data

Hua Zheng0 个研究点目标入组 4,800 人开始时间: 2016年1月1日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
4,800
主要终点
Incidence of Postoperative Delirium Within 7 Days After Kidney Transplantation

研究概览

简要总结

This study aims to develop and prospectively validate a machine learning-based prediction model for postoperative delirium in kidney transplant recipients, using perioperative clinical data. Delirium is a common and serious postoperative complication that significantly increases morbidity, mortality, and healthcare costs. By analyzing electronic medical records from kidney transplant patients, including preoperative, intraoperative, and postoperative variables, the study seeks to identify high-risk patients and key predictors. Six machine learning models, including XGBoost, LGBM, GBC, LR, ANN, and SVM, will be constructed and evaluated, with a soft voting ensemble classifier used to optimize prediction performance. The goal is to improve early recognition and clinical management of postoperative delirium in kidney transplant patients.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
16 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who underwent kidney transplantation at [Hospital Name, if needed] between January 1, 2016, and May 31,
  • Age ≥ 18 years at the time of transplantation.
  • Discharged alive from the hospital after surgery.
  • Complete perioperative clinical data available, including preoperative evaluations, intraoperative records, and postoperative documentation

排除标准

  • Patients with documented pre-existing delirium or major neurocognitive disorder before surgery.
  • Simultaneous or multi-organ transplantation (e.g., kidney-pancreas).
  • Death within 7 days postoperatively.
  • Incomplete or missing key electronic medical records preventing outcome assessment.
  • Patients who withdrew consent for use of clinical data for research purposes (for prospective part).

结局指标

主要结局

Incidence of Postoperative Delirium Within 7 Days After Kidney Transplantation

时间窗: 7 days after surgery

Postoperative delirium will be identified within 7 days of surgery through automated extraction and structured analysis of electronic medical record text fields, including progress notes, nursing records, and medication orders for sedatives or anxiolytics. Delirium will be categorized by onset time, severity, treatment, and recovery status.

次要结局

未报告次要终点

研究者

发起方
Hua Zheng
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Hua Zheng

Professor

Huazhong University of Science and Technology

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