Salivary cortisol response and VO2max during standardized excercise test in children with and without asthma - Salivary cortisol response and VO2max in children with and without asthma

Martini Ziekenhuis0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Group 1: Healthy children
•boys age 8-12 years
•prepuberal according to Tanner stage
•BMI -1.1 to 1.1 SD
•No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 2: Children with asthma
•boys age 8-12 years
•prepuberal according to Tanner stage
•BMI -1.1 to 1.1 SD
•stable asthma (no change in maintenance medication and no systemic steroids in previous 3 months)
•Maintenance dose of inhaled corticosteroids < 500 microgram per day (fluticasone equivalent)
•Normal pulmonary function (FEV1 > 90% of predicted value)
•No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 3: children with newly diagnosed asthma
•boys age 8-12 years
•prepuberal according to Tanner stage
•BMI -1.1 to 1.1 SD
•No use of inhaled corticosteroids and no systemic steroids in previous 6 months
•Normal pulmonary function (FEV1 > 90% of predicted value)
•No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school)

•No informed consent
•If exercise test are contraindicated due to physical condition or comorbidity as judged by treating physisian
•If the child does not cooperate or does not want to continue the tests
•Use of medication which may potentially affect steroid metabolism

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