NCT01015144已完成不适用
The Influence of Atorvastatin on the Parameters of Inflammation and the Function of Left Ventricle in Patients With Dilated Cardiomyopathy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 主要终点
- left ventricular function
研究概览
简要总结
The aim of the study was to assess of the influence of atorvastatin on selected indicators of an inflammatory condition, function of the left ventricle and factors affecting the occurrence of undesired events like rehospitalizations and mortality in patients with dilated cardiomyopathy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients 18 years old or older
- •patients who signed informed consent
- •patients with dilated cardiomyopathy (according ESC 2007)
- •patients who had no significant coronary artery stenoses >30% on cardiac catheterization
排除标准
- •BP ≥140/90 lub <90/60
- •congenital heart disease
- •acquired valvular disease except for mitral incompetence secondary to left ventricular dilatation
- •New York Heart Association (NYHA) functional class IV
- •statin treatment
- •preserved hyperactivity of aminotransferases with unexplained etiology,
- •muscle disorders which might cause drug-induced myopathy,
- •uncontrolled diabetes,
- •liver diseases,
- •creatinine level > 2 mg/dl and/or GFR<30ml/min,
- •abuse of alcohol or drugs,
- •chronic inflammatory diseases,
- •pregnancy or lactation,
- •severe hypothyroidism,
- •immunosuppressive treatment,
- •operation or severe injury during last month
- •vaccination during last 3 months
- •heart stimulation device or implantable cardioverter defibrillator
- •or who didn't write conscious consent
研究组 & 干预措施
Atorvastatin
干预措施: Tulip (Drug)
结局指标
主要结局
left ventricular function
时间窗: 2 months
次要结局
- mortality(6 months)
研究者
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