Explorative Proteomics to Ease the Diagnosis of Pediatric Neuroborreliosis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Protein concentrations
研究概览
简要总结
This study aims to use proteomic analysis to diagnose Lyme Neuroborreliosis (LNB) in children. Pediatric patients with suspected LNB will be enrolled, and their blood samples will be collected for proteomic analyses. Mass spectrometry will be used to compare protein profiles of LNB-positive and LNB-negative patients. The data will be analyzed by bioinformaticians. The expected impact is to establish a non-invasive, reliable method for early LNB diagnosis to improve patient outcomes.
详细描述
Objective:
The primary objective of this study is to investigate the utility of proteomic analysis in diagnosing lyme neuroborreliosis (LNB) in children. By identifying specific protein markers associated with LNB (proteomics), the investigators aim to enhance early detection and improve patient outcomes.
Methods:
Participant Recruitment:
The investigators will enroll pediatric patients (aged 1 month to 17 years) presenting with suspected LNB.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting at a pediatric ward with facial nerve palsy and/or suspicion of lyme neuroborreliosis
- •Parental informed consent
排除标准
- •Parents or legal guardians unable to understand given information or comply with study criteria
- •Patient unable to cooperate to study procedures (blood sample)
- •Unclear etiology after lumbar puncture
结局指标
主要结局
Protein concentrations
时间窗: An average of 2 years from enrollment
A matrix of concentrations of various proteins potentially relevant in diagnosing lyme neuroborreliosis.
次要结局
未报告次要终点
研究者
Joakim Bloch
Principal Investigator, Medical Doctor
Rigshospitalet, Denmark