Targeted Proteomic Analysis in the Plasma of Children With Diabetes Type 1 and Its Association With Peripheral Diabetic Neuropathy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Type 1
- Sponsor
- Aristotle University Of Thessaloniki
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Targeted proteomic analysis in children with DT1 (levels of certain plasma proteomics such as sorbitol, fructose, myo-inositol, scyllo-inositol, serine, lysine, tertadecanoic, palmitic, stearic, eicosanoic fatty acids)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy.
Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM.
In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.
Investigators
Assimina Galli-Tsinopoulou
Professor
Aristotle University Of Thessaloniki
Eligibility Criteria
Inclusion Criteria
- •Children with confirmed DT1 under insulin substitution therapy
- •Age 5-10 years
- •Good glycemic control with HbA1c ≤ 7.0%
- •Prepubertal patients
- •Absence of other diseases
- •Signed informed consent of the parents or guardians of patients
Exclusion Criteria
- •Presence of organic cause for neuropathy
- •Presence of other chronic disease
- •Poor glycemic control
Outcomes
Primary Outcomes
Targeted proteomic analysis in children with DT1 (levels of certain plasma proteomics such as sorbitol, fructose, myo-inositol, scyllo-inositol, serine, lysine, tertadecanoic, palmitic, stearic, eicosanoic fatty acids)
Time Frame: 2018-2020
Secondary Outcomes
- Electrophysiological study(2018-2020)