Association of Acquired Uterine Abnormalities With Recurrent Miscarriage
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 400
- 主要终点
- Prevalence of Acquired Uterine Anomalies
研究概览
简要总结
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
详细描述
High-quality studies including several meta-analyses have proven the association between congenital uterine anomalies and recurrent miscarriages. Nevertheless, there are limited studies evaluating the impact of acquired uterine anomalies on recurrent miscarriages.
This prospective observational study will aim to compare the prevalence of acquired uterine anomalies between the study group and the control group. The secondary aim will be to compare the Endometrial morphological features like endometrial volume, endometrial and sub-endometrial vascularity between the two groups
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women between the age group of 18-40 years
- •Women who have had 2 or more pregnancy losses before 24 weeks of gestation - Study group.
- •Women who can provide documented informed consent
- •Women with proven fertility with at least one child - Control group
排除标准
- •Women with previous history of miscarriage/ extreme preterm delivery (before 28 weeks of gestation) will be excluded from the Control group.
结局指标
主要结局
Prevalence of Acquired Uterine Anomalies
时间窗: 24 months
Primary outcome will be to compare the prevalence of acquired uterine anomalies (estimated as the proportion of anomalies diagnosed on 3D pelvic ultrasound) between study group and control group
次要结局
- Endometrial thickness(24 months)
- Endometrial blood flow indices (vascularisation index, flow index and vascularisation flow index)(24 months)
- Endometrial volume(24 months)