Predictive Factors of Endometrial Lesions in Patients With Abnormal Uterine Bleeding

Beijing Friendship Hospital1 site in 1 country900 target enrollmentOctober 1, 2021

ConditionsEndometrial Neoplasms

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Endometrial Neoplasms
Sponsor: Beijing Friendship Hospital
Enrollment: 900
Locations: 1
Primary Endpoint: pathology of endometrial lesions
Status: Active, not recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To explore the risk factors of endometrial lesions in patients with abnormal uterine bleeding and establish prediction models which can discriminate between different endometrial etiologies of abnormal uterine bleeding(AUB).

Registry

clinicaltrials.gov

Start Date

October 1, 2021

End Date

December 1, 2022

Last Updated

3 years ago

Study Type

Observational

Sex

Female

Investigators

Sponsor

Beijing Friendship Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•non-pregnancy related abnormal uttering bleeding（AUB） in women of 18-60 years old; 2)women who had indications for hysteroscopy and endometrial histology in the study period

Exclusion Criteria

•postmenopausal women, 2) AUB due to other causes such as hormones or medications, coagulation disorders, and vascular malformation of the uterus; 3) final diagnosis outside the scope of this study.

Outcomes

Primary Outcomes

pathology of endometrial lesions

Time Frame: 1 year

Endometrial tissue was curettaged and sent for pathological examination in 10% formalin. A senior pathologist who was not blinded to clinical and ultrasound information examined the samples and determined the final diagnosis. The outcomes of histology are classified as normal endometrium and endometrial lesions, which include 1)endometrial polyps,2)endometrial hyperplasia without atypia, 3)endometrial atypical hyperplasia and 4) endometrial carcinoma.