Association of Acquired Uterine Abnormalities With Recurrent Miscarriage
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Recurrent Miscarriage
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
- Enrollment
- 400
- Primary Endpoint
- Prevalence of Acquired Uterine Anomalies
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
Detailed Description
High-quality studies including several meta-analyses have proven the association between congenital uterine anomalies and recurrent miscarriages. Nevertheless, there are limited studies evaluating the impact of acquired uterine anomalies on recurrent miscarriages. This prospective observational study will aim to compare the prevalence of acquired uterine anomalies between the study group and the control group. The secondary aim will be to compare the Endometrial morphological features like endometrial volume, endometrial and sub-endometrial vascularity between the two groups
Investigators
Eligibility Criteria
Inclusion Criteria
- •Women between the age group of 18-40 years
- •Women who have had 2 or more pregnancy losses before 24 weeks of gestation - Study group.
- •Women who can provide documented informed consent
- •Women with proven fertility with at least one child - Control group
Exclusion Criteria
- •Women with previous history of miscarriage/ extreme preterm delivery (before 28 weeks of gestation) will be excluded from the Control group.
Outcomes
Primary Outcomes
Prevalence of Acquired Uterine Anomalies
Time Frame: 24 months
Primary outcome will be to compare the prevalence of acquired uterine anomalies (estimated as the proportion of anomalies diagnosed on 3D pelvic ultrasound) between study group and control group
Secondary Outcomes
- Endometrial thickness(24 months)
- Endometrial blood flow indices (vascularisation index, flow index and vascularisation flow index)(24 months)
- Endometrial volume(24 months)