ACTRN12624000364572尚未招募1 期
Terlipressin for the treatment of refractory hypotension in patients otherwise ready for discharge.
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Adults (>=18 years of age)
- •Admitted to the SCGH ICU
- •Requiring IV vasopressors (metaraminol, noradrenaline, central or peripheral) for more than 6 hours
- •Rate of less than 10 mcg/min of noradrenaline
排除标准
- •Inadequate tissue oxygenation ((lactate > 2 mmol plus any acute rise in creatinine by at least 50 mmol/l within 24 hours), or acute rise in ALT > 3x)
- •Mesenteric ischaemia or recent laparotomy
- •Hypovolemic shock (uncorrected) or hypotension due to adrenal insufficiency (if a serum cortisol assessment had been performed for clinical reasons
- •Severe organic heart disease (EF < 35%, recent MI or heart failure (last month))
- •Uncontrolled hypertension
- •Conditions that may be exacerbated by fluid overload (chronic renal failure, cardiac disease)
- •Uncorrected hypokalemia (<3) or hypomagnesemia (< 0.6) as may prolong QT interval
- •Hyponatraemia – Na <130
- •Women between the ages of 18-55 who have not had a surgical hysterectomy will only be eligible or for inclusion if they have a negative urine pregnancy test.
- •Pregnancy testing will not need to be repeated if there is a documented negative urine pregnancy test that was obtained within 7 days prior to starting study drug, provided the woman was an ICU inpatient throughout that period of time.
研究者
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