Effect of Intermittent Hypoxia on Balance Control During Standing and Walking in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Ankle plantarflexion torque
研究概览
简要总结
This study aims to determine the effect of acute mild intermittent hypoxia on ankle plantarflexor muscle output during balance regulation and walking in younger and older adults. Fifteen younger adults and 15 older adults will be recruited to participate in the cross-over design study that requires 2 visits (at least 1-week apart). Participants will be pseudo-randomly assigned to receive either intermittent hypoxia or sham during the first visit, and then switch over to receive sham or intermittent hypoxia during the 2nd visit. Muscle activation patterns and kinetic and kinematics during standing and walking will be recorded before and after the intermittent hypoxia/sham. It is hypothesized that compared to the sham condition, both younger and older participants will show greater increases in ankle plantarflexor muscle activation during gait and balance assessments following intermittent hypoxia.
详细描述
Procedure:
This is a cross-over design study that requires 2 visits (at least 1-week apart). Fifteen younger adults and 15 older adults will be recruited. Participants will be pseudo-randomly assigned to receive either intermittent hypoxia or sham during the first visit, and then switch over to receive sham or intermittent hypoxia during the 2nd visit.
During each visit, participants will first perform Gait and Balance Assessments (PRE), followed by the Intermittent Hypoxia (or sham) protocol, and then perform Gait and Balance Assessments (POST) again. The total time is approximately 2.5 hours for each visit.
Balance and Gait Assessments The consent process and Balance and Gait Assessments will take place in BEL 530.
During Balance and Gait Assessments, participants will be asked to wear tight-fitting shorts and shirt for accurate marker positioning. Approximately 39 reflective markers will be attached to target locations on the individuals' body (the head, arms, wrists, hands, trunk, pelvis, legs and feet) according to the Vicon Full-Body Plug-In Gait Model.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Participants will not be informed about which condition (intermittent hypoxia or normoxia) they are experiencing.
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to stand and walk for more than 5 minutes without assistance.
排除标准
- •Have high blood pressure (above 130/90 mmHg)
- •Are smokers
- •Are pregnant
- •Have body mass index more than 35 kg/m2
- •Have a history of falls in the past 6 months
- •Have a history of neuromuscular deficits that may affect gait
- •Have a history of cardiovascular disease
- •Have a history of diabetes or lung disease
- •Are taking medication affecting the cardiovascular system
结局指标
主要结局
Ankle plantarflexion torque
时间窗: pre (20 minutes before) and post (20 minutes after) intermittent hypoxia or sham session
Changes in peak ankle plantarflexion torque production during walking from pre to post intermittent hypoxia will be calculated.
Soleus muscle activation pattern
时间窗: pre (2o minutes before) and post (20 minutes after) intermittent hypoxia or sham session
changes in peak soleus muscle EMG magnitude following perturbation onset during standing from pre to post intermittent hypoxia will be calculated
次要结局
未报告次要终点
研究者
Hao-Yuan Hsiao
Assistant Professor
University of Texas at Austin