Implication of Aortic Cross Clamping Time Upon Postoperative Respiratory Function in Adult Patients Undergoing Open Heart Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- quality of oxygenation
研究概览
简要总结
Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.
详细描述
Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients
- •elective open heart surgery
排除标准
- •Patients with myocardial ischemia or previous infarction
- •low ejection fraction <30%
- •history of AF
- •implanted pacemaker
- •uncontrolled hypertension
- •renal impairment (creatinine >1.8 mg/dl)
- •hepatic dysfunction
- •insulin dependent diabetes
- •chronic pulmonary disease
研究组 & 干预措施
group S
short time <90 m aortic cross clamping
干预措施: aortic cross clamping (Procedure)
group L
> 90 minutes aortic cross clamping
干预措施: aortic cross clamping (Procedure)
结局指标
主要结局
quality of oxygenation
时间窗: 48 hours postoperative
PaO2 mmHg
次要结局
- ventilation(48 hours postoperative)
- carbon dioxide(48 hours)
- time to extubation(24 hours postoperative)
研究者
Emad Zarief , MD
Lecturer of Anesthesia and critical care Medicine
Assiut University