Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Major cardiac adverse outcome
研究概览
简要总结
To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.
详细描述
This study will enroll 50 patients with ST-segment elevation myocardial infarction (STEMI). Peripheral blood will be collected from these patients for immune cell subset analysis, serum cytokine evaluation, and neutrophil sorting for transcriptome sequencing. At 1 week after admission, cardiac magnetic resonance (CMR) will be performed to evaluate the myocardial salvage index, area of late gadolinium enhancement (LGE), microvascular obstruction (MVO), extracellular volume (ECV), and left ventricular ejection fraction (LVEF).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •---- Age > 18 and ≤ 80 years old
- •- Patients with acute STEMI within 12 hours of symptom onset who are planned to receive PPCI
排除标准
- •Prior revascularization
- •Known allergy to gadopentetate dimeglumine contrast agent
- •Pregnancy or planned pregnancy within the next 6 months
- •Life expectancy < 1 year
- •Metallic implants or claustrophobia that precluded MRI
- •Severe COPD or inability to hold breath for MRI
- •Severe hepatic or renal dysfunction (ALT > 5×ULN or eGFR < 15 mL/min/1.73 m²)
研究组 & 干预措施
STEMI patients
Patients with acute STEMI within 12 hours of symptom onset receive primary percutaneous coronary intervention.
结局指标
主要结局
Major cardiac adverse outcome
时间窗: At 12 months after enrollment
The composite endpoint included cardiac death, non-fatal myocardial infarction, and rehospitalization for angina.
次要结局
- Cardiac remodeling measured by CMR(At 1 week after admission)
研究者
Yi Zhang, MD, PhD
Consultant
Shanghai 10th People's Hospital