Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Neutrophil characteristics
研究概览
简要总结
In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Case Inclusion Criteria:
- •sepsis patient in the ICU with a breathing tube
- •Control Inclusion Criteria:
- •scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure
- •Plan to have endotracheal tube for planned procedures.
排除标准
- •On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)
研究组 & 干预措施
Sepsis Patients
干预措施: Sepsis (Other)
Control Patients
结局指标
主要结局
Neutrophil characteristics
时间窗: One day
measure and report β2 integrin expression on neutrophils from blood and tracheal aspirate between sepsis patients and non-sepsis patients in pediatric population
次要结局
未报告次要终点
研究者
Koichi Yuki
Cardiac Anesthesiologist
Boston Children's Hospital