To Explore the Effect of Probiotic Supplements in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Blood Urea Nitrogen (BUN) levels
研究概览
简要总结
This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with Chronic kidney disease.
详细描述
Chronic kidney disease (CKD) with gut microbiota was different from a normal person. Some gut microbiota produces short-chain fatty acids or induces functional enzymes beneficial to patients. On the other hand, some gut microbiota may also metabolize amino acids into p-cresol and indole which were leading to the accumulation of urinary toxins and damage to the kidney. This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins, inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with CKD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Blood Urea Nitrogen (BUN) levels
时间窗: Baseline to 24 week
Blood Urea Nitrogen
Estimated glomerular filtration rate (eGFR) measurement
时间窗: Baseline to 24 week
The eGFR level is a maker for kidney function
Electrolytes Analysis
时间窗: Baseline to 24 week
The concentration of electrolytes analysis in the subject's blood samples
次要结局
- Lipid analysis(Baseline to 24 week)
- 24-hour Dietary recall(Baseline to 24 week)
- The quality of life(Baseline to 24 week)
- Complete Blood Count (CBC) Test(Baseline to 24 week)
- Uremic toxins assay(Baseline to 24 week)
- Sugar test(Baseline to 24 week)
- Inflammation makers(Baseline to 24 week)
- Urine Analysis(Baseline to 24 week)
- Safety and compliance(Baseline to 24 week)
- Grip strength levels(Baseline to 24 week)
- Nutrition status(Baseline to 24 week)
- Liver function(Baseline to 24 week)