Duloxetine for chronic osteoarthritis pain; an important alternative? - DUO-trial

Erasmus MC0 个研究点目标入组 224 人开始时间: 2015年5月6日最近更新: 2020年7月6日

适应症

试验速览

暂无简介。

•1) having hip or knee OA based on the clinical ACR criteria, and 2) having chronic pain (most days of the last three months) in hip or knee, and 3)either: (i) a contra-indication for NSAIDs, (ii) adverse reactions of NSAIDs; or (iii) insufficient benefit of NSAIDs.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 112
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 112

•1) on waiting list for hip/knee replacement, and 2) use of antidepressants and neuropathic pain medication 3) contra-indication of duloxetine (use of Monoamine Oxidase Inhibitors, having uncontrolled narrow-angle glaucoma, in combination with (other) central nervous system acting drugs, in combination with thioridazine, hypersensitivity to duloxetine, disturbed liver function, renal insufficiency (creatinine clearance <30 ml/min), usage of strong CYP1A2-inhibitors and CYP2D6-inhibitors and substrates)

发起方