Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 143
- 试验地点
- 3
- 主要终点
- Quantification of specific cytokines of the Th17 immune response (IL-17 A and IL-23) in the serum
研究概览
简要总结
The aim of this open, controlled, multicentre biomedical research study is to identify new markers specifically associated with Horton's disease. This would make it possible to improve the diagnosis and management of this disease.
Participation consists in taking one or several blood samples depending on the group patients/controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who have provided written informed consent
- •Patients with national health insurance cover
- •Age: 50 to 90 years
- •Patients with Horton' s disease :
- •at the diagnosis, before any treatment
- •or in remission
- •or in relapse
- •Patients with an infectious disease :
- •Bacteriologically or radiologically confirmed
- •Presenting an inflammatory syndrome defined by :
- •CRP ≥ 10 mg / L
- •and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1
- •Patients with neoplasia ( solid tumour or hemopathy ) :
- •At the diagnosis, before treatment by chemotherapy
- •Presenting an inflammatory syndrome defined by:
- •CRP ≥ 10 mg / L
- •and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1
- •These are healthy volunteers recruited among blood donators at Dijon CHU, voluntary hospital personnel ( nurses, doctors and secretaries ), patients at the EPHAD ( Champmaillot centre for geriatric patients ) and patients without infectious, inflammatory, or auto-immune disease ( CRP < 5mg / L ) or cancer recruited from the investigating departments of Dijon CHU. They will be matched for age and sex.
- •Age: 18 - 90 years
- •Patients with national health insurance cover
- •who have provided written informed consent
- •Absence of an inflammatory syndrome ( CRP < 5 mg / L )
- •Exclusion Criteria :
- •Any patient who does not meet the inclusion criteria
排除标准
- 未提供
结局指标
主要结局
Quantification of specific cytokines of the Th17 immune response (IL-17 A and IL-23) in the serum
时间窗: Up to 6 months
Measurement of the activation level of genes specifically involved in Th17 response using RT-PCR on frozen mRNA
时间窗: Up to 6 months
Quantification of LTh17 by flow cytometry
时间窗: Up to 6 months
Measure the ability of Treg to proliferate and to synthesize IL-17 in response to different antigenic stimulations
时间窗: Up to 6 months
次要结局
未报告次要终点