The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Change in Performance of Daily Activities
研究概览
简要总结
The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •60-90 years of age
- •Living independently (not residing in an assisted living facility)
- •Through testing are found not to have sarcopenia
- •Gait speed > 1 m/s
- •Skeletal Muscle Index > 37% in men and > 27.6 % in women
- •Exclusion Criteria
- •Responding with a "yes" to any question on the PAR-Q.
- •Are currently pregnant, or plan to try and become pregnant during the study
- •Functional impairments that could impede the person's ability to participate in a resistance training program
- •Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.
- •Are currently enrolled in a regular exercise program (more than once per week)
- •Current or recent smoker
- •Use of medication containing corticosteroids
- •Mini-mental score of 21 or below
- •Severe musculoskeletal impairment
- •Uncontrolled chronic disease
- •Major depression
- •Severe vestibular problems
排除标准
- •Adults unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant women
- •Prisoners
研究组 & 干预措施
Beta-alanine and muscular endurance exercise
Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
干预措施: Muscular endurance exercise (Behavioral)
Placebo and muscular endurance exercise
Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
干预措施: Placebo (Dietary Supplement)
Placebo and muscular endurance exercise
Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
干预措施: Muscular endurance exercise (Behavioral)
Placebo without muscular endurance training
Receive similar dextrose placebo with no endurance resistance training for 12 weeks
干预措施: Placebo (Dietary Supplement)
Beta-alanine without muscular endurance training
Receive 3.2 g/day beta-alanine with no endurance resistance training for 12 weeks
干预措施: Beta-alanine (Dietary Supplement)
Beta-alanine and muscular endurance exercise
Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
干预措施: Beta-alanine (Dietary Supplement)
结局指标
主要结局
Change in Performance of Daily Activities
时间窗: baseline, 12 weeks
Short Physical Functional Performance test
次要结局
- Change in Muscular Endurance(baseline, 12 weeks)
- Change in Muscular Strength(baseline, 12 weeks)
- Change in Body Fat(baseline, 12 weeks)
研究者
Joseph Signorile
Professor
University of Miami