A Pilot Test to Evaluate the Effect of Maternal Stress on Breastmilk Quantity and Stress Biomarkers in Mothers and Their Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Correlation between secretory IgA levels in mother's serum and reported stress
研究概览
简要总结
The overall goal of this research is to clarify the relationship between reported maternal stress, biological measures of maternal stress, breast milk biomarkers and milk quantity. Our primary hypothesis is that measures of maternal stress are associated with cortisol, cytokines, and other stress markers in the blood, which impacts breast milk quantity and composition and which may impact infant health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Baby will remain in mom's legal custody
- •Intends to exclusively breastfeed during the NICU stay
- •Has kept a daily log of milk expression (pump or hand expression) with date/time/quantity since birth of their child
- •Less than 7 days postpartum
排除标准
- •Baby and mother are to be separated due to legal custody issues
- •Medical contraindication to breastfeeding
- •Non-English speaking
- •Unable to answer a written survey in English
- •More than 50% of infant intake is not mother's own milk at 4 weeks postpartum
结局指标
主要结局
Correlation between secretory IgA levels in mother's serum and reported stress
时间窗: 1 month
Mother's stress will be measured using the The Parent Stress Scale: Neonatal Intensive Care Unit. This scale ranges from 1-130 with higher numbers indicating more stress. Serum will be collected from mothers at enrollment and 4 weeks postpartum. Maternal venipuncture will be used to collect an 0.5mL aliquot of whole blood at the time of mother's first morning pump session in the neonatal intensive care unit. IgA will be quantitated using the Millipore Magpix 100 System. Multivariate regression analysis will be used to test for correlations.
次要结局
未报告次要终点
研究者
Casey Rosen-Carole
Assistant Professor
University of Rochester