Prevalence and Prognostic Implications of Cardiac Injury in Patients With Influenza-like Illness
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 466
- 试验地点
- 1
- 主要终点
- Level of biochemical markers
研究概览
简要总结
This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.
详细描述
The relationship between influenza and cardiovascular events was described in an early study of influenza epidemics from 1915 to 1929 including the 1918-1920 pandemic. Retrospective studies have shown increased risk for acute myocardial infarction (AMI) during the first week following an infection with influenza.
Biochemical markers of cardiac injury such as high sensitive cardiac troponins may be increased during infection with influenza. Increased levels of cardiac troponins are associated with adverse outcome in many different populations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (>18 years) presenting with influenza-like illness.
- •Written informed consent.
排除标准
- •Inability to provide informed consent.
- •Age <18 years.
- •Symptoms indicating an acute coronary syndrome, acute heart failure, rapid atrial fibrillation or acute stroke.
结局指标
主要结局
Level of biochemical markers
时间窗: One year
Level of other biochemical markers in patients with influenza
次要结局
- Prognostic implication(One year)
研究者
Anna Nordenskjöld
Principal Investigator
Örebro University, Sweden