Investigation of Ghrelin Levels in Patients With Protein C Deficiency
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- acyl ghrelin and des acyl ghrelin measured in mg/dl
研究概览
简要总结
In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.
30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.
If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •protein C deficiency or healthy subjects
- •age 18-70
- •BMI 18-35
- •written statement to join the study
排除标准
- •chronic illness, apart from protein C deficiency and lifestyle diseases
- •everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.
- •blood donation within three months prior to the investigation.
- •Alcohol abuse
结局指标
主要结局
acyl ghrelin and des acyl ghrelin measured in mg/dl
时间窗: 6 month
次要结局
- Growth hormone measured in pmol/L(6 month)