Per Effort Study of Inflammatory Consequences of an Ultra Endurance Race (165km)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 主要终点
- Per and post-exertional variations of IL6 during an ultra-endurance race in healthy volunteers.
研究概览
简要总结
The aim of this study is to study the per and post-exertional variations of the pro and anti inflammatory markers during an ultra-endurance race in healthy volunteers.
详细描述
Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male older than 18 years,
- •Completion of an ultra-endurance race (distance greater than 50 kilometers) during the 24 months preceding the race.
- •Affiliation or beneficiary of a social security.
排除标准
- •Age lower than 18 years,
- •Subjects with a medical history (pulmonary pathology, cardiac, hypertension) or with a significant chronic inflammatory disease observed during the inclusion visit (the day before the race).
结局指标
主要结局
Per and post-exertional variations of IL6 during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of IL6 blood level
Per and post-exertional variations of IL1 during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of IL1 blood level
Per and post-exertional variations of HMG beta during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of HMG beta blood level
Per and post-exertional variations of TNF alpha during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of TNF alpha blood level
Per and post-exertional variations of IL13 during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of IL13 blood level
Per and post-exertional variations of lipids during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of lipids blood level
Per and post-exertional variations of CRP during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of CRP blood level
Per and post-exertional variations of IL4 during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of IL4 blood level
Per and post-exertional variations of IL10 during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of IL10 blood level
Per and post-exertional variations of LPS during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of LPS blood level
Per and post-exertional variations of lipoprotein during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of lipoprotein blood level
Per and post-exertional variations of TGF beta during an ultra-endurance race in healthy volunteers.
时间窗: Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race
In this study, the investigators will measure variations of TGF beta blood level
次要结局
未报告次要终点
研究者
Romain Jouffroy
Principal Investigator
Hôpital Necker-Enfants Malades