Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- ovum pickup rate that took place between Sunday to Thursday without a compromise
研究概览
简要总结
The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.
详细描述
A randomised controlled trial in which study group will be given estrogen derivative before ovarian stimulation in GnRH antagonist protocol and compared to the classical GnRH agonist protocol.Estrogen will be given P.O , "PROGYNOVA' , in a dose of 2 mg /d, starting day 2 of menses and until first Monday to follow. Main outcome measure will be ability to control the ovum pickup day, calculated as a rate of ideal pickups divided by the entire pickup number. All women enrolled will be under 38 years of age, with a clear indication for IVF other than ovulatory dysfunction. women with past 4 treatment failures will be excluded as well as cases in which sperm achieved in surgical methods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 38 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •IVF treatment in the following indications: Male, Mechanical, Unexplained
- •Age<38 years
- •Treatment Cycle number 1-4
排除标准
- •Ovulatory disorder as an indication for IVF
- •Repeated failure in previous IVF treatments (> than 4 cycles)
- •Sperm used for treatment was retrieved by surgical procedure
研究组 & 干预措施
Follicular Estrogen, Antagonist, IVF
Follicular Estrogen in Antagonist IVF protocol
干预措施: estradiol valerate (Drug)
long IVF protocol
long IVF protocol
干预措施: estradiol valerate (Drug)
结局指标
主要结局
ovum pickup rate that took place between Sunday to Thursday without a compromise
时间窗: a year
number of Pickups that took place between Sunday to Thursday (without a compromise in treatment) \\ by the entire pickup number
次要结局
- pregnancy rate(a year)