The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Cerebral Vascular Reactivity to Hypercapnia
研究概览
简要总结
Brain blood flow regulation will be measured in response to environmental changes using MRI.
详细描述
Global brain blood flow decreases with advancing age; however, some adults have accelerated declines in brain blood flow, placing them at a greater risk of cognitive impairment. Similarly, brain reactivity to increased levels of carbon dioxide decreases with age, with a greater decline in adults with vascular risk factors and is impaired in early Alzheimer's disease. Preclinical models suggest that reduced brain blood flow, results in low levels of oxygen regionally. Currently, there are a lack of human studies that investigate the cause or consequence of altered blood flow regulation in the brain.
The research aims are:
- Determine the impact of vertebral artery hypoplasia (VAH) on brain reactivity to increased levels of carbon dioxide.
- Determine the impact of VAH on the brain blood flow response to acute low levels of oxygen.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI ≤38.5 kg/m2
- •Nonsmoker
- •Female subjects: postmenopausal
- •Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core
排除标准
- •Diagnosis of mild cognitive impairment or Alzheimer's disease
- •Uncontrolled hypertension
- •History or evidence of hepatic disease, hematological disease, or peripheral vascular disease
- •Severe kidney injury requiring hemodialysis
- •Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
- •History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
- •History of HIV/AIDS
- •Severe untreated obstructive sleep apnea
- •History of diabetes with HbA1c greater than 9.5%
- •Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.)
- •Current or recent (<1 year) major psychiatric condition (Axis I) or addictive disorders
- •Contraindications to MRI
结局指标
主要结局
Cerebral Vascular Reactivity to Hypercapnia
时间窗: One study visit, up to 120 minutes in the MRI
The change in brain blood flow using MRI will be measured in response to a hypercapnic breathing test. The participants cerebral vascular reactivity to hypercapnia will be compared between the controls (without VAH) and those with VAH.
Cerebral Blood Flow Response to Hypoxia
时间窗: One study visit, up to 120 minutes in the MRI
The change in brain blood flow using MRI will be measured in response to a hypoxic breathing test. The participants cerebral blood flow response to hypoxia will be compared between the controls (without VAH) and those with VAH.
次要结局
未报告次要终点