Therapeutic evaluation of Neuropharmacological effects of Roghan-e-Banafsha Nasal drops in the patients of Insomnia: An exploratory/ pilot Clinical study

Insomnia, characterized by difficulty in initiating or maintaining sleep, affects a significant portion of the population, often leading to various psychological and physical impairments. Sleep (Yaqza) is one of the important factor mentioned in six essential factors (Asbab Sitta Daruriyya) of life, which works throughout the life in every individual Unani medicine offers natural therapeutic options, with Roghan-e-Banafsha (Viola odorata) being traditionally used to treat sleep disorders. This pilot study aims to evaluate the neuropharmacological effects and safety of Roghan-e-Banafsha nasal drops in the management of insomnia. The study will enroll 20 adult patients diagnosed with insomnia. Participants received two drops of Roghan-e-Banafsha nasally before bedtime over a period of four weeks. Efficacy was assessed using the ISI, with results compared at baseline and the end of the intervention. Safety was evaluated through standard pre- and post-treatment investigations. Initial findings suggest that Roghan-e-Banafsha may provide a non-invasive, cost effective alternative to conventional sedatives, improving sleep quality with minimal side effects. This study could contribute to the broader use of nasal delivery systems for herbal remedies in treating neurological conditions like anxiety, depression. Further research with larger sample sizes is recommended to confirm these finding and explore additional therapeutic applications.